What Is Whole Exome Sequencing?

Whole Exome Sequencing (WES) is a cutting-edge genetic test that decodes all protein-coding regions of your genome, known as exons. These regions make up just 1–2% of the DNA but contain 85% of known disease-causing mutations.

WES is highly effective in diagnosing rare diseases, unexplained medical conditions, developmental delays, and even assessing your cancer risk. It’s trusted globally for providing a personalized, gene-level insight into your health.

Why Choose Whole Exome Sequencing In Dubai?

? Covers Over 20,000 Genes In One Test
? Ideal For Children With Developmental Delays Or Autism
? Helps Diagnose Neurological And Rare Genetic Disorders
? Guides Cancer Risk Assessment And Targeted Treatment
? Performed In Dubai’s Top Genetic Testing Labs
⏱️ Fast Turnaround – 2 To 4 Weeks

Who Should Consider Whole Exome Sequencing?

✔️ Individuals With Unexplained Health Conditions Or Symptoms
✔️ Children With Autism, Seizures, Or Developmental Delays
✔️ Families With A History Of Genetic Disorders
✔️ Cancer Patients For Tumor Genetic Profiling
✔️ Couples Planning A Family For Carrier Screening
✔️ Anyone Interested In A Complete Genetic Health Overview

Benefits Of Whole Exome Sequencing

✨ Comprehensive Gene Analysis In One Test
✨ Detects Hidden Or Rare Mutations Missed By Standard Tests
✨ Supports Early Diagnosis And Personalized Treatment
✨ Non-Invasive Sample Collection (Blood Or Saliva)
✨ Used In Pediatrics, Oncology, Cardiology, And Neurology

Procedure Of The Test

1. Sample Collection

   • A blood or saliva sample is collected from the patient or the family trio (parents + child).

2. DNA Extraction & Sequencing

   • DNA is extracted and sequenced using Next-Generation Sequencing (NGS) platforms.

3. Bioinformatics Analysis

   • Thousands of genes are analyzed using advanced algorithms to detect variants.

4. Clinical Interpretation

   • A team of geneticists reviews the findings and prepares a clinically actionable report.

5. Genetic Counseling (Optional)

   • Personalized guidance is available to help understand the results and next steps.

Methodology Of Test

Whole Exome Sequencing is powered by Next-Generation Sequencing (NGS) technology, which enables rapid and comprehensive gene analysis.

? Key Technical Highlights:

• Platform: Illumina / Thermo Fisher

• Coverage: ≥100x mean coverage for high confidence

• Regions Targeted: All ~20,000 protein-coding genes (exons)

• Analysis: Variant calling, annotation, and classification (benign, likely pathogenic, VUS, etc.)

• Reporting: Includes disease-causing variants, incidental findings (if opted), and carrier status

? WES is ideal for cases with unclear diagnosis, complex symptoms, or multi-system involvement.

Conclusion

Whole Exome Sequencing (WES) is revolutionizing the way diseases are diagnosed and managed. Whether you're seeking answers for a rare or inherited disorder, exploring your child’s unexplained symptoms, or looking to assess your cancer or cardiac risk, WES offers clarity and actionable insights.