? What Is The Somatic HRR Panel?
The Somatic HRR (Homologous Recombination Repair) Panel is a next-generation sequencing (NGS) test that detects mutations in key DNA repair genes such as BRCA1, BRCA2, ATM, PALB2, CHEK2, and more. These genes are crucial for repairing damaged DNA, and mutations may indicate increased cancer risk, sensitivity to PARP inhibitors, or potential resistance to standard therapies.

? Why Take This Test In Dubai?

✔️ Detects actionable mutations in 15+ HRR-related genes
✔️ Supports personalized treatment in ovarian, breast, pancreatic, and prostate cancers
✔️ Helps determine eligibility for PARP inhibitors
✔️ Aids in tumor profiling for advanced cancer management
✔️ Available in leading oncology labs and hospitals in Dubai

? Methodology Of The Test

1. Sample Collection:
   A tumor biopsy sample (formalin-fixed paraffin-embedded tissue) is collected. In some cases, blood samples may also be used.

2. DNA Extraction:
   DNA is extracted from the tumor tissue for mutation analysis.

3. NGS Sequencing:
   High-throughput sequencing is performed to assess mutations in HRR-related genes.

4. Bioinformatics Analysis:
   Detected mutations are analyzed for clinical significance using validated databases and algorithms.

5. Reporting:
   A detailed report is generated within 10–14 business days, outlining mutations, clinical impact, and potential therapies.

? When Should You Consider The HRR Panel?

• If diagnosed with advanced-stage breast, ovarian, prostate, or pancreatic cancer
• When tumor profiling is required for targeted therapy planning
• Prior to prescribing PARP inhibitors (e.g., Olaparib, Niraparib)
• To understand tumor biology and resistance pathways
• For second-line treatment decisions after chemotherapy

? Cost Of Somatic HRR Panel In Dubai

The price typically ranges between AED 4,500 – AED 8,500, depending on the lab, type of cancer, and whether genetic counseling is included

?‍♀️ Frequently Asked Questions (FAQ)

Q1: What does the HRR panel test for?
It tests for somatic mutations in homologous recombination repair genes, which can guide cancer treatment and therapy response.

Q2: Is this the same as BRCA testing?
It includes BRCA1/2, but covers many additional DNA repair genes, offering a broader view than BRCA-only testing.

Q3: Who should take this test?
It’s ideal for patients with solid tumors like breast, ovarian, prostate, or pancreatic cancer, especially in advanced stages.

Q4: Does this test determine cancer risk?
No, this test looks at tumor mutations, not inherited (germline) ones. For risk assessment, a germline genetic test is recommended.

Q5: Can the results help decide treatment?
Yes, it helps identify patients who may benefit from PARP inhibitors or other targeted therapies.

✅ Conclusion
The Somatic HRR Panel is an essential test for anyone battling or managing advanced-stage cancers in Dubai. It offers vital insights into the genetic architecture of tumors, empowering doctors to select the most effective, personalized therapies. With access to world-class healthcare facilities in Dubai, you can now harness the power of genomic medicine to guide your treatment journey. Ask your oncologist today about the Somatic HRR Panel — and take control of your cancer care.