What Is ROS1 FISH Test?

The ROS1 FISH (Fluorescence In Situ Hybridization) test is a highly specialized genetic test used to detect ROS1 gene rearrangements in cancer cells, most commonly in non-small cell lung cancer (NSCLC).

ROS1 rearrangements occur in a small percentage of lung cancer patients but are highly responsive to targeted therapies like crizotinib. This test helps doctors identify whether a patient is suitable for personalized treatment with ROS1 inhibitors, significantly improving outcomes.

Why Choose ROS1 FISH Test In Dubai?

? High Sensitivity Genetic Test – Detects chromosomal translocations in ROS1
? Supports Targeted Therapy – Identifies patients for ROS1 inhibitor treatment
? Essential For NSCLC Management
? Offered In Dubai’s Leading Molecular Oncology Labs
? Fast Turnaround Time – 5 To 10 Working Days
? Performed On Tumor Biopsy Sample (FFPE)

Who Should Get The ROS1 FISH Test?

✔️ Patients With Newly Diagnosed Non-Small Cell Lung Cancer (NSCLC)
✔️ Individuals With Adenocarcinoma Subtype
✔️ Patients Negative For EGFR, ALK, And KRAS Mutations
✔️ Young Non-Smokers With Lung Cancer
✔️ Candidates Being Evaluated For Targeted Therapy Options

Benefits Of ROS1 FISH Test

✨ Enables Precision Oncology – Choose therapies based on tumor genetics
✨ Non-Invasive – Performed on previously collected biopsy/surgical specimen
✨ Helps Avoid Ineffective Chemotherapy
✨ Globally Recognized Diagnostic Method
✨ Improves Treatment Response And Survival Rates

Procedure Of The Test

1. Sample Collection

   • The test uses a formalin-fixed paraffin-embedded (FFPE) tissue block or slide from a previous biopsy or surgery.

2. FISH Technique Execution

   • Fluorescent probes specific to the ROS1 gene are applied to the tissue slide.

3. Microscopic Analysis

   • A specialist uses a fluorescent microscope to examine the number and position of ROS1 gene signals.

4. Interpretation

   • A positive ROS1 rearrangement indicates potential benefit from ROS1-targeted therapies like crizotinib.

Methodology Of The Test

The ROS1 FISH Test uses the Fluorescence In Situ Hybridization (FISH) technique for detecting genetic alterations in tumor cells.

? How It Works:

• Dual-colored DNA probes are used to label different ends of the ROS1 gene.

• If the signals appear split apart (rather than overlapping), it confirms a ROS1 gene rearrangement.

? Test Highlights:

• Performed on FFPE tissue sections

• Interpretation by trained molecular pathologists

• Highly specific for ROS1 fusion events

This method is recognized by CAP/ASCO guidelines and is a standard of care in modern lung cancer diagnostics.

Conclusion

The ROS1 FISH Test is a vital tool in the precision treatment of lung cancer, especially for patients with non-small cell lung cancer in Dubai. By detecting ROS1 gene rearrangements, this test helps guide life-changing targeted therapies that are often more effective and have fewer side effects than traditional chemotherapy.

? If you or your loved one is undergoing cancer diagnosis or treatment, talk to your oncologist about getting the ROS1 FISH Test—a step toward personalized, effective care.