? What Is The Oncomine MPN Panel Test?
The Oncomine Myeloproliferative Neoplasm (MPN) Panel is a next-generation sequencing (NGS) test that accurately detects mutations in genes commonly associated with MPNs, including JAK2, CALR, and MPL. These genetic alterations help classify the type of MPN, assess disease progression, and guide treatment strategies.

? Why Is This Test Popular In Dubai?

✔️ Detects key MPN mutations: JAK2 V617F, CALR exon 9, MPL W515
✔️ Assists in early diagnosis and precise classification of MPNs
✔️ Helps differentiate between ET, PV, and MF subtypes
✔️ Supports selection of targeted therapy and monitoring strategies
✔️ Available in top-tier hospitals and labs in Dubai

? Methodology Of The Test

1. Sample Collection:
   A peripheral blood or bone marrow aspirate is collected in a sterile tube.

2. DNA Extraction:
   Genomic DNA is isolated for high-sensitivity mutation detection.

3. NGS Analysis:
   The DNA is sequenced using targeted NGS technology, focusing on the MPN-related genes.

4. Data Interpretation:
   Results are analyzed using advanced software to identify mutations and their clinical significance.

5. Clinical Report:
   A comprehensive report is issued within 10–12 working days, with actionable insights for physicians.

? When Should You Consider This Test?

• If you have abnormal blood counts, such as high platelets or red blood cells
• When MPN is suspected due to clinical signs like splenomegaly, fatigue, or clotting issues
• For confirmation after a bone marrow biopsy
• Before starting targeted therapies like JAK inhibitors
• To evaluate family history or hereditary risk in MPN

? Cost Of The Oncomine MPN Panel In Dubai

The typical cost ranges from AED 3,500 – AED 6,500, depending on the lab, report urgency, and inclusion of genetic counseling services.

?‍♀️ Frequently Asked Questions (FAQ)

Q1: What is an MPN and why is genetic testing important?
An MPN is a group of blood cancers where the bone marrow produces too many blood cells. Genetic testing helps in diagnosing, monitoring, and selecting the right targeted therapies.

Q2: What are the main mutations detected in this panel?
The panel focuses on JAK2, CALR, and MPL mutations, which are the most common in MPNs like Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Myelofibrosis (MF).

Q3: Is this test painful?
The test only requires a blood draw or bone marrow sample, which is a routine and quick procedure.

Q4: How accurate is the Oncomine MPN Panel?
It offers high sensitivity and specificity, even detecting low-frequency mutations, making it ideal for early-stage diagnosis.

Q5: Can this test be done during treatment?
Yes. It is also used to monitor disease progression or treatment response, especially for patients on JAK inhibitors.

✅ Conclusion
The Oncomine Myeloproliferative Neoplasm (MPN) Panel is a cutting-edge tool for diagnosing and managing MPNs with unmatched precision. In a healthcare hub like Dubai, this test empowers hematologists with accurate insights to deliver personalized, targeted treatments for patients with myeloid cancers. Whether you're just starting your diagnostic journey or fine-tuning your therapy, this panel is the smart step forward.