? What Is The Oncomine Myeloid RNA Panel Test?
The Oncomine Myeloid RNA Panel is a next-generation sequencing (NGS) test that focuses on identifying gene fusions and transcript variants in myeloid malignancies. It plays a critical role in diagnosing and characterizing conditions such as Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS), and other related cancers by uncovering RNA-level alterations that DNA-only panels may miss.

? Why Is This Test Important In Dubai?

✔️ Detects clinically relevant fusion transcripts like PML-RARA, RUNX1-RUNX1T1, CBFB-MYH11, BCR-ABL1
✔️ Helps refine diagnosis for myeloid neoplasms and mixed lineage leukemias
✔️ Critical for identifying candidates for targeted fusion-specific therapies
✔️ Fast, accurate, and trusted by top hematology centers across Dubai
✔️ Enhances detection in cases where DNA mutations are absent

? Methodology Of The Test

1. Sample Collection:
   A bone marrow aspirate or peripheral blood sample is collected.

2. RNA Extraction:
   Total RNA is isolated from the sample to study gene expression and fusions.

3. NGS-Based Sequencing:
   The RNA undergoes targeted sequencing to identify transcript variants and fusion genes.

4. Bioinformatics Processing:
   Data is processed using clinical-grade algorithms to filter relevant fusions.

5. Result Reporting:
   A comprehensive clinical report is delivered within 10–14 working days, including therapeutic relevance.

? When Should You Take This Test?

• At initial diagnosis of AML or MDS
• If fusion genes are suspected from cytogenetic analysis
• When DNA panels return inconclusive results
• Before selecting targeted treatments like arsenic trioxide or tyrosine kinase inhibitors
• To confirm diagnosis of specific subtypes of leukemia

? Cost Of Oncomine Myeloid RNA Panel In Dubai

Prices typically range from AED 4,500 – AED 8,000, depending on the laboratory and whether it is bundled with DNA panel testing or genetic counseling.

?‍♀️ Frequently Asked Questions (FAQ)

Q1: What is the benefit of testing RNA over DNA?
RNA testing is superior in detecting gene fusions and splicing variants, which are often not visible in DNA-based tests.

Q2: Can this test detect rare leukemic fusions?
Yes. It is specifically designed to uncover low-frequency or cryptic gene fusions that other platforms might miss.

Q3: Is this test suitable for pediatric patients?
Absolutely. It is highly useful in pediatric leukemia, especially for precise classification and treatment guidance.

Q4: How soon are the results available?
The results are usually ready in 10 to 14 business days.

Q5: Is a bone marrow sample necessary?
In most cases, yes — as bone marrow typically contains more relevant RNA. However, blood samples may be used depending on disease stage.

✅ Conclusion
The Oncomine Myeloid RNA Panel is an advanced and essential tool for detecting fusion genes and transcript abnormalities in myeloid malignancies. Its role in precision medicine is unmatched — particularly in Dubai, where world-class healthcare meets cutting-edge diagnostics. Whether you’re in the early diagnostic phase or refining treatment strategies, this test brings unmatched clarity and confidence to your medical journey. Speak to your hematologist or oncologist today and explore this advanced testing option.