? What Is The JAK2 V617F Mutation Analysis?
The JAK2 V617F Mutation Test detects a specific mutation in exon 14 of the JAK2 gene, which is commonly associated with myeloproliferative neoplasms (MPNs) such as Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF). Using real-time PCR technology, this test provides highly sensitive detection of this mutation from a blood sample.

? Why Is This Test Important In Dubai?

✔️ Identifies the JAK2 V617F mutation, present in over 95% of PV cases
✔️ Critical for confirming diagnosis of chronic myeloproliferative disorders
✔️ Helps differentiate between reactive and clonal blood disorders
✔️ Quick turnaround time using advanced PCR technology
✔️ Available in Dubai’s leading diagnostic laboratories

? Methodology Of The Test

1. Sample Collection:
   A blood sample is drawn using a standard venipuncture technique.

2. DNA Extraction:
   White blood cells are separated and DNA is extracted from them.

3. Real-Time PCR Amplification:
   The extracted DNA is amplified using quantitative real-time PCR, which detects the V617F point mutation.

4. Result Interpretation:
   The PCR machine analyzes fluorescent signals to confirm the presence or absence of the mutation.

5. Reporting:
   A detailed clinical report is generated within 3–5 working days.

? When Should You Take This Test?

• When there's unexplained increase in red blood cells or platelets
• If MPN is suspected due to symptoms like splenomegaly, fatigue, or clotting
• For patients with thrombocytosis or erythrocytosis
• To confirm diagnosis of PV, ET, or MF
• When advised by a hematologist or oncologist

? Cost Of JAK2 V617F Test In Dubai

The price for this real-time PCR test usually ranges between AED 600 – AED 1,200, depending on the clinic and urgency of reporting.

?‍♀️ Frequently Asked Questions (FAQ)

Q1: What does a positive JAK2 V617F result mean?
A positive result indicates a mutation in the JAK2 gene, commonly found in patients with MPNs like PV, ET, or MF.

Q2: Is this test hereditary?
No, the V617F mutation is somatic, meaning it is acquired and not inherited.

Q3: Can this test be used for treatment decisions?
Yes. Identifying the mutation helps guide treatment plans, including use of JAK inhibitors.

Q4: Is fasting required before the test?
No fasting is required. It's a simple blood test.

Q5: Can the test be repeated?
Yes. It can be used for monitoring mutation load during treatment or disease progression.

✅ Conclusion
The JAK2 V617F Mutation Analysis (Real-Time PCR) is a powerful, fast, and essential diagnostic tool for detecting myeloproliferative neoplasms. If you're in Dubai and experiencing unusual blood counts or have been advised to check for blood-related cancers, this test can provide the answers your doctors need. With quick results and accurate diagnostics, you’re one step closer to personalized care and peace of mind. Book your test today at a trusted Dubai lab.