? What Is The Focus Fusion Panel (52 Genes)?
The Focus Fusion Panel (52 Genes) is a powerful RNA-based next-generation sequencing (NGS) test designed to detect clinically relevant gene fusions across a wide range of cancers. This test screens for transcript fusions in 52 critical genes that are known to drive various tumor types, including lung, thyroid, sarcoma, hematologic, and gastrointestinal cancers.

? Why Choose This Test In Dubai?

✔️ Detects fusion events in 52 high-priority oncogenes
✔️ Improves diagnosis of rare or complex cancers
✔️ Enables targeted therapy selection based on actionable fusion drivers
✔️ Trusted by leading oncology centers in Dubai
✔️ Ideal for both solid tumors and hematological malignancies

? Methodology Of The Test

1. Sample Collection:
   Tumor tissue (FFPE block or slide) is collected. In some cases, a liquid biopsy (blood) may be acceptable.

2. RNA Extraction:
   Total RNA is extracted from the sample for fusion analysis.

3. Targeted NGS Sequencing:
   The test uses amplicon-based RNA sequencing to identify known and novel gene fusions.

4. Bioinformatics Pipeline:
   Fusion detection is carried out using advanced algorithms with high sensitivity and specificity.

5. Report Generation:
   Results are delivered within 10–14 working days, including clinical interpretation and therapy suggestions.

? When Should You Consider The Focus Fusion Panel?

• When the tumor is fusion-driven (e.g., ALK, ROS1, RET in lung cancer)
• In rare or undifferentiated tumors lacking a clear diagnosis
• To assess eligibility for targeted drugs (e.g., NTRK inhibitors, ALK inhibitors)
• For patients non-responsive to standard chemotherapy
• During second-line treatment planning or clinical trial enrollment

? Cost Of The Focus Fusion Panel In Dubai

The cost typically ranges from AED 5,000 – AED 9,000, depending on tumor type, sample condition, and hospital.

?‍♀️ Frequently Asked Questions (FAQ)

Q1: What cancers can this panel detect fusions in?
It’s useful in a variety of cancers including lung, thyroid, brain, gastrointestinal, soft tissue sarcomas, and hematologic malignancies.

Q2: How does this differ from DNA panels?
DNA panels detect mutations, while the Focus Fusion Panel detects RNA transcript-level fusions, which are often more relevant for targeted therapies.

Q3: Can this panel detect rare or unknown fusions?
Yes. It’s designed to detect both known and novel fusions using powerful algorithms.

Q4: Is the test painful or invasive?
Not at all. It uses already available tumor samples (biopsy tissue or slides), with no additional procedures needed.

Q5: Is this test suitable for pediatric patients?
Yes, especially in pediatric sarcomas or leukemias, where gene fusions are common.

✅ Conclusion
The Focus Fusion Panel (52 Genes) offers an advanced genomic lens into the biology of cancer, helping doctors in Dubai detect fusion-driven tumors and select precision therapies that can transform outcomes. Whether you're dealing with a challenging diagnosis, treatment resistance, or exploring clinical trials, this test provides the clarity you need. Ask your oncologist today about the Focus Fusion Panel and move closer to personalized cancer care.